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CO 2 -Induced Panic Attacks: A Twin Study

1998; American Psychiatric Association; Volume: 155; Issue: 9 Linguagem: Inglês

10.1176/ajp.155.9.1184

1535-7228

Laura Bellodi, Giampaolo Perna, Daniela Caldirola, Cinzia Arancio, Angelo Bertani, Daniela Di Bella,

Heart Rate Variability and Autonomic Control

Objective: The authors investigated the role of genetic factors in 35% CO2-induced panic attacks.Method: Ninety twins recruited from general population were challenged with one-vital capacity inhalations of 35% CO2–65% O2. Probandwise concordance rates were calculated and rates compared for monozygotic and for dizygotic twins.Results: A significantly higher concordance was found for 35% CO2-induced panic attacks among monozygotic than dizygotic twins (55.6% versus 12.5%).Conclusions: These results suggest a relevant role of genetic factors in 35% CO2-induced panic attacks. Am J Psychiatry 1998; 155: 1184-1188