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JAK2V617F allele burden is associated with transformation to myelofibrosis

2012; Taylor & Francis; Volume: 53; Issue: 11 Linguagem: Inglês

10.3109/10428194.2012.682308

1042-8194

Maya Koren‐Michowitz, Yosef Landman, Yoram Cohen, Naomi Rahimi‐Levene, Ophira Salomon, Maria Michael, Ninette Amariglio, Arnon Nagler,

Eosinophilic Disorders and Syndromes

The JAK2V617F mutation has emerged in recent years as a diagnostic as well as treatment target in patients with polycythemia vera (PV). We analyzed JAK2V617F allele burden (JAK2(V617F)) in a Jewish population with PV. Results were correlated with disease symptoms and complications. Median JAK2(V617F) was 48% and 54% in patients of Ashkenazi and non-Ashkenazi origin, respectively (p =0.75). Higher JAK2(V617F) was seen in patients with imaging-proven splenomegaly (p =0.01). A correlation between JAK2(V617F) and the weekly hydoxyurea dose needed for disease control was found (p =0.043). In addition, a trend for higher allele burden in patients with longer disease duration (p =0.064) and those treated with cytoreductive drugs other than hydroxyurea (p =0.056) was noted. Higher JAK2(V617F) was seen in patients with transformation to myelofibosis (p =0.0001), but not in patients with vascular complications. JAK2(V617F) may assist in prognostic stratification of patients with PV.