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A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose

2010; Taylor & Francis; Volume: 48; Issue: 5 Linguagem: Inglês

10.3109/15563650.2010.486381

1556-9519

Vikhyat S. Bebarta, Louise Kao, Blake Froberg, Richard F. Clark, Eric J. Lavonas, Ming Qi, João Delgado, John McDonagh, Tom Arnold, Oladapo Odujebe, Gerry O'Malley, Claudia Lares, Elizabeth Aguilera, Richard C. Dart, Kennon Heard, Chriss Stanford, Jamie Kokko, Greg Bogdan, Carrie D. Mendoza, Sara Mlynarchek, Sean H. Rhyee, Jason Hoppe, William Haur, Hock Heng Tan, Nguyen Nguyen Tran, Shawn M. Varney, Amy Zosel, Jennifer Buchanan, Mohammed Al-Helial,

Pharmacological Effects and Toxicity Studies

Oral and intravenous (IV) N-acetylcysteine (NAC) are used for the treatment of acetaminophen poisoning. The objective of this multicenter study was to compare the safety of these two routes of administration. Methods. We conducted a multicenter chart review of all patients treated with NAC for acetaminophen poisoning. The primary safety outcome was the percentage of patients with NAC-related adverse events. Results. A total of 503 subjects were included in the safety analysis (306 IV-only, 145 oral-only, and 52 both routes). There were no serious adverse events related to NAC for either route. Nausea and vomiting were the most common related adverse events and were more common with oral treatment (23 vs. 9%). Anaphylactoid reactions were more common with IV administration (6 vs. 2%). Conclusions. IV and oral NAC are generally mild adverse drug reactions.