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Inflammation markers in healthy and periodontitis patients: a preliminary data screening

2008; Fundação Odontológica de Ribeirão Preto; Volume: 19; Issue: 1 Linguagem: Inglês

10.1590/s0103-64402008000100001

1806-4760

Adriana Corrêa de Queiroz, Mário Taba, Patricia A. O'Connell, Priscila Brasil da Nóbrega, Priscila Paganini Costa, Viviane Keiko dos Santos Kawata, Glauce Lunardelli Trevisan, Arthur B. Novaes, Sérgio Luı́s Scombatti de Souza, Daniela Bazan Palioto, Márcio Fernando de Moraes Grisi,

S100 Proteins and Annexins

Advances in diagnostic research are moving towards methods whereby the periodontal risk can be identified and quantified by objective measures using biomarkers. Patients with periodontitis may have elevated circulating levels of specific inflammatory markers that can be correlated to the severity of the disease. The purpose of this study was to evaluate whether differences in the serum levels of inflammatory biomarkers are differentially expressed in healthy and periodontitis patients. Twenty-five patients (8 healthy patients and 17 chronic periodontitis patients) were enrolled in the study. A 15 mL blood sample was used for identification of the inflammatory markers, with a human inflammatory flow cytometry multiplex assay. Among 24 assessed cytokines, only 3 (RANTES, MIG and Eotaxin) were statistically different between groups (p<0.05). In conclusion, some of the selected markers of inflammation are differentially expressed in healthy and periodontitis patients. Cytokine profile analysis may be further explored to distinguish the periodontitis patients from the ones free of disease and also to be used as a measure of risk. The present data, however, are limited and larger sample size studies are required to validate the findings of the specific biomarkers.