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Systems biology of skeletal muscle: fiber type as an organizing principle

2012; Wiley; Volume: 4; Issue: 5 Linguagem: Inglês

10.1002/wsbm.1184

1939-5094

Sarah M. Greising, Heather M. Gransee, Carlos B. Mantilla, Gary C. Sieck,

Muscle activation and electromyography studies

Abstract Skeletal muscle force generation and contraction are fundamental to countless aspects of human life. The complexity of skeletal muscle physiology is simplified by fiber type classification where differences are observed from neuromuscular transmission to release of intracellular Ca 2+ from the sarcoplasmic reticulum and the resulting recruitment and cycling of cross‐bridges. This review uses fiber type classification as an organizing and simplifying principle to explore the complex interactions between the major proteins involved in muscle force generation and contraction. WIREs Syst Biol Med 2012. doi: 10.1002/wsbm.1184 This article is categorized under: Physiology > Mammalian Physiology in Health and Disease Models of Systems Properties and Processes > Organ, Tissue, and Physiological Models