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When Is Structure, Function? Revisiting an Old Concept in Atrial Fibrillation

2015; Wiley; Volume: 26; Issue: 12 Linguagem: Inglês

10.1111/jce.12836

1540-8167

Junaid Zaman, Sanjiv M. Narayan,

Cardiac Arrhythmias and Treatments

Journal of Cardiovascular ElectrophysiologyVolume 26, Issue 12 p. 1361-1363 Editorial Comment When Is Structure, Function? Revisiting an Old Concept in Atrial Fibrillation JUNAID A. B. ZAMAN M.A., B.M.B.Ch., M.R.C.P., JUNAID A. B. ZAMAN M.A., B.M.B.Ch., M.R.C.P. Department of Medicine, Stanford University, Palo Alto, California, USA National Heart & Lung Institute, Imperial College London, UKSearch for more papers by this authorSANJIV M. NARAYAN M.D., F.R.C.P., Corresponding Author SANJIV M. NARAYAN M.D., F.R.C.P. Department of Medicine, Stanford University, Palo Alto, California, USAAddress for correspondence: Sanjiv Narayan, M.D., Ph.D., Stanford University, Palo Alto CA 94305, USA. Fax: +1-650-724-6131; E-mail: [email protected]Search for more papers by this author JUNAID A. B. ZAMAN M.A., B.M.B.Ch., M.R.C.P., JUNAID A. B. ZAMAN M.A., B.M.B.Ch., M.R.C.P. Department of Medicine, Stanford University, Palo Alto, California, USA National Heart & Lung Institute, Imperial College London, UKSearch for more papers by this authorSANJIV M. NARAYAN M.D., F.R.C.P., Corresponding Author SANJIV M. NARAYAN M.D., F.R.C.P. Department of Medicine, Stanford University, Palo Alto, California, USAAddress for correspondence: Sanjiv Narayan, M.D., Ph.D., Stanford University, Palo Alto CA 94305, USA. Fax: +1-650-724-6131; E-mail: [email protected]Search for more papers by this author First published: 11 September 2015 https://doi.org/10.1111/jce.12836Citations: 3 Dr. Zaman was supported by the Fulbright Commission and British Heart Foundation. He reports travel support from Atricure. Dr. Narayan was supported in part by grants from the NIH (R01 HL 83359, K24 HL103800). Dr. Narayan reports being co-inventor on intellectual property owned by the University of California and licensed to Topera Medical, Inc., in which he has held equity. Dr. Narayan reports having received consulting fees from Medtronic, St. Jude Medical, UpToDate and Janssen Pharmaceuticals. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1Mines G: On dynamic equilbrium in the heart. J Physiol 1913; 46: 349-383. 2Mazgalev TN, Ho SY, Anderson RH: Anatomic-electrophysiological correlations concerning the pathways for atrioventricular conduction. Circulation 2001; 103: 2660-2667. 3Mechulan A, Gula LJ, Klein GJ, Leong-Sit P, Obeyesekere M, Krahn AD, Yee R, Skanes AC: Further evidence for the “Muscle Bundle” hypothesis of cavotricuspid isthmus conduction: Physiological proof, with clinical implications for ablation. J Cardiovasc Electrophysiol 2013; 24: 47-52. 4Feld GK, Fleck RP, Chen PS, Boyce K, Bahnson TD, Stein JB, Calisi CM, Ibarra M: Radiofrequency catheter ablation for the treatment of human type 1 atrial flutter. Identification of a critical zone in the reentrant circuit by endocardial mapping techniques. Circulation 1992; 86: 1233-1240. 5Peters NS, Wit AL: Myocardial architecture and ventricular arrhythmogenesis. Circulation 1998; 97: 1746-1754. 6de Bakker JM, van Capelle FJ, Janse MJ, Tasseron S, Vermeulen JT, de Jonge N, Lahpor JR: Slow conduction in the infarcted human heart. “Zigzag” course of activation. Circulation 1993; 88: 915-926. 7Stevenson WG, Khan H, Sager P, Saxon LA, Middlekauff HR, Natterson PD, Wiener I: Identification of reentry circuit sites during catheter mapping and radiofrequency ablation of ventricular tachycardia late after myocardial infarction. Circulation 1993; 88: 1647-1670. 8de Jong S, van Veen TAB, van Rijen HVM, de Bakker JMT: Fibrosis and cardiac arrhythmias. Journal Cardiovasc Pharmacol 2011; 57: 630-638. 9Oakes RS, Badger TJ, Kholmovski EG, Akoum N, Burgon NS, Fish EN, Blauer JJE, Rao SN, DiBella EVR, Segerson NM, Daccarett M, Windfelder J, McGann CJ, Parker D, MacLeod RS, Marrouche NF: Detection and quantification of left atrial structural remodeling with delayed-enhancement magnetic resonance imaging in patients with atrial fibrillation. Circulation 2009; 119: 1758-1767. 10Gramley F, Lorenzen J, Knackstedt C, Rana OR, Saygili E, Frechen D, Stanzel S, Pezzella F, Koellensperger E, Weiss C, Münzel T, Schauerte P: Age-related atrial fibrosis. Age (Dordrecht, Netherlands) 2009; 31: 27-38. 11Hansen BJ, Zhao J, Csepe TA, Moore BT, Li N, Jayne LA, Kalyanasundaram A, Lim P, Bratasz A, Powell KA, Simonetti OP, Higgins RSD, Kilic A, Mohler PJ, Janssen PML, Weiss R, Hummel JD, Fedorov VV: Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts. Eur Heart J 2015; 36: 2390-2401. 12Ten Tusscher KHWJ, Panfilov AV: Influence of diffuse fibrosis on wave propagation in human ventricular tissue. Europace 2007: 9 Suppl 6, vi38-vi45. 13Engelman ZJ, Trew ML, Smaill BH: Structural heterogeneity alone is a sufficient substrate for dynamic instability and altered restitution. Circ Arrhythm Electrophysiol 2010; 3: 195-203. 14Xie Y, Sato D, Garfinkel A, Qu Z, Weiss JN: So little source, so much sink: Requirements for afterdepolarizations to propagate in tissue. Biophysical J 2010; 99: 1408-1415. 15Yue L, Xie J, Nattel S: Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res 2011: 744-753. 16Angel N, Li L, Macleod RS, Marrouche NF, Ranjan R, Dosdall DJ: Diverse fibrosis architecture and premature stimulation facilitate initiation of reentrant activity following chronic atrial fibrillation. J Cardiovasc Electrophysiol 2015; 26: 1352-1360. 17Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA: Atrial fibrillation begets atrial fibrillation: A study in awake chronically instrumented goats. Circulation 1995; 92: 1954-1968. 18Schricker AA, Lalani GG, Krummen DE, Rappel W-J, Narayan SM: Human atrial fibrillation initiates via organized rather than disorganized mechanisms. Circ Arrhythm Electrophysiol 2014; 7: 816-824. 19Lalani GG, Schricker A, Gibson M, Rostamian A, Krummen DE, Narayan SM: Atrial conduction slows immediately before the onset of human atrial fibrillation: A bi-atrial contact mapping study of transitions to atrial fibrillation. J Am Coll Cardiol 2012; 59: 595-606. 20Stiles MK, John B, Wong CX, Kuklik P, Brooks AG, Lau DH, Dimitri H, Roberts-Thomson KC, Wilson L, De Sciscio P, Young GD, Sanders P: Paroxysmal lone atrial fibrillation is associated with an abnormal atrial substrate: Characterizing the “second factor.” J Am Coll Cardiol 2009; 53: 1182-1191. 21Jalife J: Mechanisms of persistent atrial fibrillation. Curr Opin Cardiol 2014; 29: 20-27. 22Wakili R, Voigt N, Kääb S: Recent advances in the molecular pathophysiology of atrial fibrillation. J Clin Invest 2011; 121: 2955-2968. 23Kirubakaran S, Chowdhury RA, Hall MCS, Patel PM, Garratt CJ, Peters NS: Fractionation of electrograms is caused by co-localised conduction block and connexin disorganization in the absence of fibrosis as af becomes persistent in the goat model. Heart Rhythm 2015; 12: 397-408. 24Severs NJ, Bruce AF, Dupont E, Rothery S: Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc Res 2008; 80: 9-19. 25Fry CH, Gray RP, Dhillon PS, Jabr RI, Dupont E, Patel PM, Peters NS: Architectural correlates of myocardial conduction: Changes to the topography of cellular coupling, intracellular conductance and action potential propagation with hypertrophy in guinea-pig ventricular myocardium. Circ Arrhythm Electrophysiol 2014; 7: 1198-1204. 26Zhao J, Hansen BJ, Csepe TA, Lim P, Hummel JD, Fedorov VV: Integration of high resolution optical mapping and 3D micro-CT imaging to resolve the structural basis of atrial conduction in the human heart. Circ Arrhythm Electrophysiol 2015; In press. 27Wong CX, Stiles MK, John B, Brooks AG, Lau DH, Dimitri H, Kuklik P, Shipp NJ, Sullivan T, Sanders P: Direction-dependent conduction in lone atrial fibrillation. Heart Rhythm 2010; 7: 1192-1199. 28Benharash P, Buch E, Frank P, Share M, Tung R, Shivkumar K, Mandapati R: Quantitative analysis of localized sources identified by focal impulse and rotor modulation mapping in atrial fibrillation. Circ Arrhythm Electrophysiol 2015; 8: 554-562. 29Allessie MA, de Groot, NMS, Houben RPM, Schotten U, Boersma E, Smeets JL, Crijns HJ: Electropathological substrate of long-standing persistent atrial fibrillation in patients with structural heart disease: Longitudinal dissociation. Circ Arrhythm Electrophysiol 2010; 3: 606-615. 30Narayan SM, Krummen DE, Shivkumar K, Clopton P, Rappel W-J, Miller JM: Treatment of atrial fibrillation by the ablation of localized sources. J Am Coll Cardiol 2012; 60: 628-636. 31Narayan SM, Krummen DE, Rappel W-J: Clinical mapping approach to diagnose electrical rotors and focal impulse sources for human atrial fibrillation. J Cardiovasc Electrophysiol 2012; 23: 447-454. 32Rappel W-J, Zaman JAB, Narayan SM: Mechanisms for the termination of atrial fibrillation by localized ablation: Computational and clinical studies. Circ Arrhythm Electrophysiol 2015; CIRCEP.115.002956. [Epub ahead of print]. 33Tanaka K, Zlochiver S, Vikstrom KL, Yamazaki M, Moreno J, Klos M, Zaitsev AV, Vaidyanathan R, Auerbach DS, Landas S, Guiraudon G, Jalife J, Berenfeld O, Kalifa J: Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure. Circ Res 2007; 101: 839-847. Citing Literature Volume26, Issue12December 2015Pages 1361-1363 ReferencesRelatedInformation