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Age‐specific risk of fetal loss post second trimester amniocentesis: analysis of 5043 cases

2007; Wiley; Volume: 27; Issue: 2 Linguagem: Inglês

10.1002/pd.1647

1097-0223

Vincenzo Mazza, Mariangela Pati, Emma Bertucci, Claudia Re, Andrea Ranzi, Antonio Percesepe, Antonino Forabosco, Annibale Volpe,

Pregnancy and preeclampsia studies

Abstract Objectives To assess the risk of fetal loss attributable to second trimester amniocentesis in singleton pregnancies through a cross‐sectional study. Methods Records of 5043 consecutive second trimester amniocentesis, performed by a single operator between 1997 and 2003, were analyzed. Fetal loss post amniocentesis was calculated by grouping pregnant women in age classes and assessing observed/expected (O/E) rate. Results Total fetal losses were 40 (0.81%): 33 cases (0.67%) occurred before the 24th week, 37 cases (0.76%) before the 28th gestational week, and 3 cases (0.06%) after the 28th week of pregnancy. An age‐dependent increase of the rate of fetal loss, not statistically significant (Chi‐Square = 0.349, p = 0.505) was observed. The total O/E ratio values did not show any statistically significant risk (O/E ratio = 1.25, CI = 0.86–1.64). The analysis of the single age classes did not detect any statistical significance. The excess fetal loss rate associated with amniocentesis was 0.16%. Conclusions No effect of the 2nd trimester amniocentesis was noted on fetal loss. Copyright © 2007 John Wiley & Sons, Ltd.