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New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain

2006; American Association for the Advancement of Science; Volume: 311; Issue: 5761 Linguagem: Inglês

10.1126/science.1119133

1095-9203

Kazunobu Sawamoto, Hynek Wichterle, Óscar González-Pérez, Jeremy A. Cholfin, Masayuki Yamada, Nathalie Spassky, Noel Murcia, José Manuel García‐Verdugo, Oscar Marı́n, John L.R. Rubenstein, Marc Tessier‐Lavigne, Hideyuki Okano, Arturo Álvarez-Buylla,

Developmental Biology and Gene Regulation

In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.