The effect of APOE genotype on clinical phenotype in Alzheimer disease
2006; Lippincott Williams & Wilkins; Volume: 67; Issue: 3 Linguagem: Inglês
10.1212/01.wnl.0000228222.17111.2a
ISSN1526-632X
AutoresWiesje M. van der Flier, S.N.M. Schoonenboom, Yolande A.L. Pijnenburg, Nick C. Fox, Philip Scheltens,
Tópico(s)Computational Drug Discovery Methods
ResumoThe authors classified 100 patients with Alzheimer disease (AD) as presenting with a memory or nonmemory phenotype. APOE genotype was determined. There was an association between APOE-epsilon4 and clinical phenotype (odds ratio = 3.0; 95% CI: 1.2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-epsilon4 allele, whereas the atypical nonmemory phenotype occurs in the absence of the APOE-epsilon4 allele.
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