Alterations of tumour suppressor gene PPP2R1B in hepatocellular carcinoma
2007; Elsevier BV; Volume: 253; Issue: 1 Linguagem: Inglês
10.1016/j.canlet.2007.01.016
ISSN1872-7980
AutoresHuei‐Chi Chou, Chien‐Hung Chen, Mei–Hsuan Lee, Cha‐Ze Lee, Guan‐Tarn Huang, Pei‐Ming Yang, Po–Huang Lee, Jin‐Chuan Sheu,
Tópico(s)Cancer Genomics and Diagnostics
ResumoTo evaluate whether the tumour suppressor gene, PPP2R1B, is involved in pathogenesis of hepatocellular carcinoma (HCC), reverse transcription-polymerase chain reaction (RT-PCR) and cDNA sequencing were performed. Eleven of 38 (29%) tumours and 1 of 34 (3%) corresponding non-tumour tissues showed coexpression of wild-type and aberrant mRNA. Various deletions were found in aberrant transcripts. Southern blot analysis did not show gene deletion in tumours, suggesting abnormal RNA splicing may be involved. These data suggest the possibility that aberrant transcripts of PPP2R1B might be associated with the development of HCC.
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