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Adverse drug reaction: rosuvastatin as a cause for ischaemic colitis in a 64-year-old woman

2012; BMJ; Volume: 2012; Issue: jun28 1 Linguagem: Inglês

10.1136/bcr.11.2011.5270

1757-790X

Jackie Tan, Casper F. Pretorius, P. V. Flanagan, Antonio Pais,

Microscopic Colitis

Rosuvastatin (Crestor, AstraZeneca) is a commonly used drug for managing hypercholesterolaemia. It is a very safe medication with mostly acceptable side effects. Rare but serious side effects are not well known. A 64-year-old woman presented with bloody diarrhoea after starting rosuvastatin for hypercholesterolaemia. Stool microscopy and culture ruled out infective causes. Abdominal CT scan revealed normal calibre celiac axis and superior mesenteric artery. Colonoscopic biopsy revealed ischaemic colitis as the final histological diagnosis. The patient is in complete remission after ceasing the medication. Rosuvastatin causing ischaemic colitis should be considered a rare but serious adverse drug reaction.