Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Refractory Disseminated Coccidioidomycosis and Mycobacteriosis in Interferon‐γ Receptor 1 Deficiency

2009; Oxford University Press; Volume: 49; Issue: 6 Linguagem: Inglês

10.1086/605532

ISSN

1537-6591

Autores

Donald C. Vinh, Fares Masannat, Robert B. Dzioba, John N. Galgiani, Steven M. Holland,

Tópico(s)

Antifungal resistance and susceptibility

Resumo

Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-gamma receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-gamma axis appears to be critical for control of coccidioidomycosis.

Referência(s)