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Spontaneous Rejection of Poorly Immunogenic P1.HTR Tumors by Stat6-Deficient Mice

2000; American Association of Immunologists; Volume: 165; Issue: 11 Linguagem: Inglês

10.4049/jimmunol.165.11.6024

1550-6606

Aalok Kacha, Francesca Fallarino, Mary A. Markiewicz, Thomas F. Gajewski,

T-cell and B-cell Immunology

Abstract Experimental evidence suggests that a type 1 T cell response may result in optimal tumor rejection in vivo. This phenotype is determined in part by cytokines that influence T cell differentiation. In transplantable tumor models such as P1.HTR, tumors grow progressively despite expression of defined tumor Ags. We hypothesized that this failure to reject may be due to poor generation of a type 1 phenotype, through a dominant influence of the type 2-promoting cytokines IL-4 and/or IL-13. This hypothesis was tested by implanting P1.HTR tumors into mice deficient in Stat6. In contrast to progressive growth of P1.HTR tumors in wild-type mice, and aggressive growth even of IL-12-transfected P1.HTR in Stat1−/− mice, P1.HTR was spontaneously rejected by Stat6−/− mice. Rejection was accompanied by augmented tumor-specific IFN-γ production and CTL activity. These results suggest that pharmacologic inhibition of Stat6 signaling could potentiate anti-tumor immunity in vivo.