Henipavirus in Pteropus vampyrus Bats, Indonesia
2006; Centers for Disease Control and Prevention; Volume: 12; Issue: 4 Linguagem: Inglês
10.3201/eid1204.051181
ISSN1080-6059
AutoresIndrawati Sendow, Hume Field, John M. Curran, Chris Morrissy, Greer Meehan, Tim D. Buick, Peter T. Daniels,
Tópico(s)Vector-Borne Animal Diseases
ResumoHenipavirus in Pteropus vampyrusBats, IndonesiaTo the Editor: The emergence of Nipah virus (NiV) in Malaysia in 1999 resulted in 265 known human infections (105 fatal), widespread infection in pigs (with >1 million culled to control the outbreak), and the collapse of the Malaysian pig export market (1).As with the closely related Hendra virus (HeV) that emerged in Australia in 1994 and caused fatal disease in horses and humans (2), bats of the genus Pteropus (commonly known as flying foxes) were identified as the major reservoir of Nipah virus in Malaysia (3,4).This report describes a serologic survey of Pteropus vampyrus in neighboring Indonesia.We nonrandomly sampled 106 P. vampyrus bats from market sellers on the Indonesian islands of Java and Sumatra during a 12-day period from July 23 to August 3, 2002 (Figure).Bats were typically caught locally by sellers.Screening by indirect enzymelinked immunosorbent assay with inactivated NiV antigen was done at the Research Institute for Veterinary Science in Bogor, Indonesia.Virus neutralization tests (VNT) with NiV and HeV were performed under biosafety level 4 conditions at the Commonwealth Scientific and Research Organization (CSIRO) Australian Animal Health Laboratory in Geelong, Australia.The gold-standard (6) VNT results are presented here; a neutralizing titer >5 was considered positive.Serum samples from 32 bats neutralized NiV (median titer 20, range 5-160), samples from 52 bats did not, and samples from 20 bats caused toxic reactions in the cell sheet at dilutions <10 (n = 7), <20 (n = 9), or <40 (n = 4), precluding a definitive test outcome.Two bats had inadequate samples for NiV VNT.Samples from 19
Referência(s)