Upregulation of Human Mammaglobin Reduces Migration and Invasion of Breast Cancer Cells
2013; Taylor & Francis; Volume: 32; Issue: 1 Linguagem: Inglês
10.3109/07357907.2013.861473
ISSN1532-4192
AutoresEun‐Ha Koh, Young‐Woo Cho, Yun‐Ja Mun, Ji Hyeon Ryu, Eun‐Jin Kim, Dae Seob Choi, Kook-Young Maeng, Jaehee Han, Dawon Kang,
Tópico(s)Cancer, Hypoxia, and Metabolism
ResumoLittle is known about the biological role of human mammaglobin (hMAM) that is considered as a promising marker for breast cancer. Here, we investigated hMAM's role related to migration and invasion of human breast cancer cells (hBCC). Compared to normal cells, hBCC have high MAM mRNA expression levels. Of the hBCC tested, MAM mRNA expression levels were higher in noninvasive than in invasive cells. Overexpression of hMAM in breast cancer cells decreased migration and invasion, whereas knockdown of hMAM increased both. Taken together, these results suggest that metastasis of hBCC could be controlled by hMAM expression levels.
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