Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary
2005; Oxford University Press; Volume: 21; Issue: 19 Linguagem: Inglês
10.1093/bioinformatics/bti430
ISSN1367-4811
AutoresX. Mao, Tommaso Cai, J. G. Olyarchuk, L. Wei,
Tópico(s)Genomics and Phylogenetic Studies
ResumoMotivation: High-throughput technologies such as DNA sequencing and microarrays have created the need for automated annotation of large sets of genes, including whole genomes, and automated identification of pathways. Ontologies, such as the popular Gene Ontology (GO), provide a common controlled vocabulary for these types of automated analysis. Yet, while GO offers tremendous value, it also has certain limitations such as the lack of direct association with pathways.
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