Blood and Tissue Level of Sulphamerazine in Chickens
2010; Wiley; Volume: 25; Issue: 2 Linguagem: Inglês
10.1111/j.1439-0442.1978.tb00913.x
ISSN0177-0543
AutoresM. Atef, Medhat A. Mohammed, S. M. Sokkar,
Tópico(s)Neuroendocrine regulation and behavior
ResumoZentralblatt für Veterinärmedizin Reihe AVolume 25, Issue 2 p. 149-154 Blood and Tissue Level of Sulphamerazine in Chickens Dr. M. Atef, Corresponding Author Dr. M. Atef College of Veterinary Medicine, Baghdad University Baghdad, IraqFaculty of Veterinary Medicine, Cairo University, Giza, Egypt.Search for more papers by this authorDr. Medhat A. Mohammed, Corresponding Author Dr. Medhat A. Mohammed College of Veterinary Medicine, Baghdad University Baghdad, IraqFaculty of Veterinary Medicine, Cairo University, Giza, Egypt.Search for more papers by this authorDr. S. M. Sokkar, Corresponding Author Dr. S. M. Sokkar College of Veterinary Medicine, Baghdad University Baghdad, IraqFaculty of Veterinary Medicine, Cairo University, Giza, Egypt.Search for more papers by this author Dr. M. Atef, Corresponding Author Dr. M. Atef College of Veterinary Medicine, Baghdad University Baghdad, IraqFaculty of Veterinary Medicine, Cairo University, Giza, Egypt.Search for more papers by this authorDr. Medhat A. Mohammed, Corresponding Author Dr. Medhat A. Mohammed College of Veterinary Medicine, Baghdad University Baghdad, IraqFaculty of Veterinary Medicine, Cairo University, Giza, Egypt.Search for more papers by this authorDr. S. M. Sokkar, Corresponding Author Dr. S. M. Sokkar College of Veterinary Medicine, Baghdad University Baghdad, IraqFaculty of Veterinary Medicine, Cairo University, Giza, Egypt.Search for more papers by this author First published: March 1978 https://doi.org/10.1111/j.1439-0442.1978.tb00913.xCitations: 6AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Summary Sulphamerazine was administered to chickens in two doses, 200 and 500 mg./kg. b. wt. by intramuscular and oral routes. The concentration of the drug in blood plasma reached its highest level during the first six hours then declined rapidly. 24 hours following administration, small amounts were detected, whereas traces or no sulphonamide were found 48 hours from the time of administration. The plasma protein binding ranged between 41.7 and 58.3 percent. Estimation of sulphamerazine in most of the body tissues revealed that all tissues had lower concentrations than plasma. The highest concentration was found in kidneys and lungs and the lowest in brain. On the other hand, sulphamerazine was N4-acetylated in the body tissues to an extent higher than that in plasma. Acetylation was highest in brain and lowest in heart muscle. Zusammenfassung Sulfamerazin-Konzentrationen im Blut und Gewebe beim Huhn Bei Hühnern wurden 200 bzw. 500 mg Sulfamerazin pro kg Körpergewicht verabreicht. In den ersten 6 Stunden erreichte das Medikament die höchste Konzentration und fiel dann rasch ab. Nach 24 Stunden wurden noch kleine Mengen des Sulfonamids gefunden, nach 48 Stunden waren nur noch Spuren oder nichts mehr nachzuweisen. 41,7–58,3% des Medikaments wurden von den Plasmaproteinen gebunden. In allen Geweben waren die Sulfamerazin-Konzentrationen geringer als im Blutplasma. Die größte Konzentration wurde in den Nieren und Lungen, die kleinste im Gehirn gefunden. In den Geweben war die N4-Azetylierung des Sulfamerazins größer als im Plasma. Am größten war die Azetylierung im Gehirn, am geringsten im Myokard. Résumé Concentrations de sulfamérazine dans le sang et les tissus chez la poule Des poules ont reçu 200 et 500 mg de sulfamérazine par kg de poids. Le médicament a atteint la plus forte concentration dans les 6 premières heures pour baisser rapidement ensuite. De petites quantités de sulfonamide furent trouvées après 24 heures, des traces ou plus rien après 48 heures. 41,7–58,3% du médicament fut lié aux protéines du plasma. Les concentrations furent constatées dans les reins et les poumons, les plus faibles dans le cerveau. La N4-acétylisation de la sulfamérazine fut plus forte dans les tissus que dans le plasma; elle fut la plus forte dans le cerveau et la plus faible dans le myocarde. Resumen Concentraciones de sulfamerazina en sangre y tejidos de gallinas Se administraron a gallinas 200 resp. 500 mg. de sulfamerazina por kg. de peso corporal. En las 6 horas primeras alcanzó el medicamento la concentración máxima, descendiendo luego con rapidez. Tras 24 horas se hallaron solo cantidades exiguas de la sulfonamida, tras 48 horas no se identificaban más que vestigios o nada. 47.1–58.3% del medicamento fueron fijados por las proteínas plasmáticas. En todos los tejidos eran menores las concentraciones de sulfamerazina que en el plasma sanguíneo. La concentración máxima se halló en riñones y pulmones, la mínima en el cerebro. En los tejidos era mayor la acetilación N4 de la sulfamerazina que en el plasma. 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