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Modulatory antibiotic activity and chemical composition of hydroalcoholic extract of Croton campestris

2011; Academic Journals; Volume: 5; Issue: 18 Linguagem: Inglês

10.5897/jmpr.9000900

1996-0875

E. B. Francisco, Edinardo Fágner Ferreira Matias, Dayanne Rakelly de Oliveira, Andreza Guedes Barbosa Ramos, Cícera Norma Fernandes, Heloísa Helena F. Souza, Luiz J. Lacerda Neto, Anita Oliveira Brito Pereira, Mariana K.A. Araruna, Francisco Antônio Vieira dos Santos, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa, Marta Regina Kerntopf, Irwin Rose Alencar de Menezes,

Ethnobotanical and Medicinal Plants Studies

Croton campestris A. St.-Hill., known as Velame do campo (Euphorbiaceae), native of the Brazilian Northeastern region, is used in the popular medicine as decoction against several diseases as inflammations, hematological disturbances, flu and gastritis. The study analyzed the chemical composition and the antibacterial activity against bacterial strains ofEscherichia coli and Staphylococcus aureus of the hydroalcoholic extract of the leaves of the C. campestris (HEFCC). The inhibition of the bacterial growth was demonstrated for the bacteria tested with MIC values ≥ 1024 µg/ml. When combined with aminoglycosides (gentamicin, kanamycin, amikacin and neomycin), the extract demonstrated synergistic effect. This result showed that HEFCC can be used as promisor font of new antimicrobial compounds for pathogenic diseases. Key words: Croton campestris, antimicrobial activity, modulatory aminoglycoside effect, antimicrobial activity, antibiotic, synergism.