Custom‐Fit Ruthenium(II) Metallopeptides: A New Twist to DNA Binding With Coordination Compounds
2013; Wiley; Volume: 19; Issue: 40 Linguagem: Inglês
10.1002/chem.201301629
ISSN1521-3765
AutoresIlaria Gamba, Iria Salvadó, Gustavo Rama, Miriam Bertazzon, Mateo I. Sánchez, Víctor M. Sánchez‐Pedregal, José Martínez‐Costas, Rosa F. Brissos, Patrick Gámez, José L. Mascareñas, Miguel Vázquez López, M. Eugenio Vázquez,
Tópico(s)DNA and Nucleic Acid Chemistry
ResumoAbstract A new bipyridine building block has been used for the solid‐phase synthesis of dinuclear DNA‐binding ruthenium(II) metallopeptides. Detailed spectroscopic studies suggest that these compounds bind to the DNA by insertion into the DNA minor groove. Moreover, the potential of the solid‐phase peptide synthesis approach is demonstrated by the straightforward synthesis of an octaarginine derivative that shows effective cellular internalization and cytotoxicity linked with strong DNA interaction, as evidenced by steady‐state fluorescence spectroscopy and AFM studies.
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