Hepcidin Regulation of Iron Transport
2008; Elsevier BV; Volume: 138; Issue: 11 Linguagem: Inglês
10.3945/jn.108.096347
ISSN1541-6100
AutoresJames F. Collins, Marianne Wessling‐Resnick, Mitchell D. Knutson,
Tópico(s)Hemoglobinopathies and Related Disorders
ResumoThe discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.
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