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Treatment History and Treatment Dose Are Important Determinants of Sulfadoxine‐Pyrimethamine Efficacy in Children with Uncomplicated Malaria in Western Kenya

2003; Oxford University Press; Volume: 187; Issue: 3 Linguagem: Inglês

10.1086/367705

1537-6613

Dianne J. Terlouw, Jeanne M. Courval, MARGARETTE S. KOLCZAK, Oren S. Rosenberg, A J Oloo, Piet A. Kager, Altaf A. Lal, Bernard L. Nahlen, Feiko O. ter Kuile,

Mosquito-borne diseases and control

This study retrospectively studied amendable determinants of sulfadoxine-pyrimethamine (SP) efficacy involving 2869 treatments among 1072 Kenyan children <5 years old who had uncomplicated malaria. The dose was based on age: one-quarter tablet was given to infants <1 year old, one-half tablet was given to 1–3-year-old children, and a full tablet was given to 4-year-old children. Only 23.5% received the internationally recommended target dose of 25/1.25 mg of SP per kg of body weight. SP intake in the previous 15–35 days (adjusted relative risk, 1.67; 95% confidence interval, 1.35–2.07) and low SP dose ( 25% of children <5 years. Many age-based dose recommendations need urgent revision, because SP is increasingly used as first-line treatment in sub-Saharan Africa