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Multiplication of Human Natural Killer Cells by Nanosized Phosphonate‐Capped Dendrimers

2007; Wiley; Volume: 46; Issue: 14 Linguagem: Inglês

10.1002/anie.200604651

1521-3773

Laurent Griffe, Mary Poupot, Patrice Marchand, Alexandrine Maraval, Cédric‐Olivier Turrin, Olivier Rolland, Pascal Métivier, G. Bacquet, Jean‐Jacques Fournié, Anne‐Marie Caminade, Rémy Poupot, Jean‐Pierre Majoral,

Immunotherapy and Immune Responses

Non-natural born killers: The addition of phosphorus-containing dendrimers capped with phosphonate end groups to cultures of human peripheral blood mononuclear cells (white blood cells) strongly stimulates the selective multiplication of functional natural killer (NK) cells (see picture), which play a key role in anticancer immunity. Both the generation of the dendrimer and the type of end groups are important criteria for the activity. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604651_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.