Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Salivary duct carcinoma: cytokeratin 14 as a marker of in‐situ intraductal growth

2002; Wiley; Volume: 41; Issue: 3 Linguagem: Inglês

10.1046/j.1365-2559.2002.01454.x

1365-2559

Vera Cavalcanti de Araújo, S V L Loducca, Ana Paula Veras Sobral, Luiz Paulo Kowalski, Fernando Augusto Soares, Ney Soares de Araújo,

Oral and Maxillofacial Pathology

Aims: The aim of this study was to determine the immunoprofile of salivary duct carcinoma and to differentiate intraductal growth from invasive growth. Methods and results: We applied a panel of antibodies (cytokeratins 7, 8, 13, 14, 19, vimentin and α‐smooth muscle actin) in five cases of salivary duct carcinoma. This panel is currently used for identification of different components of salivary gland tumours in our laboratory. All tumour cells were positive for cytokeratins 7 and 8. Few neoplastic structures expressed cytokeratin 14 in cells surrounding tumour islands. Conclusion: The finding of cytokeratin 14 was important to confirm the in‐situ intraductal growth, which probably characterizes this low‐grade neoplasm.