Novel antifungal polyene amides from the myxobacterium Cystobacter fuscus: isolation, antifungal activity and absolute structure determination
2004; Elsevier BV; Volume: 60; Issue: 45 Linguagem: Inglês
10.1016/j.tet.2004.09.013
ISSN1464-5416
AutoresBangi A. Kundim, Yu Itou, Youji Sakagami, Ryosuke Fudou, Shigeru Yamanaka, Makoto Ojika,
Tópico(s)Alkaloids: synthesis and pharmacology
ResumoThree new unstable metabolites, (6E,10Z)-2′-O-methylmyxalamide D (1), 2′-O-methylmyxalamide D (2) and (6E)-2′-O-methylmyxalamide D (3) were isolated from the myxobacterium Cystobacter fuscus. The planar structures were elucidated by spectroscopic analyses to be geometrical isomers of a polyene amide related to a myxobacterial metabolite, myxalamide D (4). Their absolute stereochemistry was determined by synthesis of degradation products. Antifungal activities of 1–3 as well as their acetates were evaluated against the phythopathogenic fungus Phythopthora capsici.
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