Copper content in Areca catechu (betel nut) products and oral submucous fibrosis
1997; Elsevier BV; Volume: 349; Issue: 9063 Linguagem: Inglês
10.1016/s0140-6736(97)24020-1
ISSN1474-547X
AutoresChet Trivedy, Dianne Baldwin, Saman Warnakulasuriya, Newell W. Johnson, T. J. Peters,
Tópico(s)Oral and Maxillofacial Pathology
ResumoChewing areca nut, alone or as a component of betel quid, is widespread in the Orient and among some emigrant populations therefrom. Populations chewing areca nut have an increased incidence of oral cancer. 1 World Health OrganizationControl of oral cancer in developing countries. Bull World Health Organ. 1984; 62: 817-830 PubMed Google Scholar Areca nut is also causally linked to oral submucous fibrosis, 2 Maher R Lee AJ Warnakulasuriya KAAS Lewis JA Johnson NW Role of areca nut in the causation of oral submucous fibrosis: a case-control study in Pakistan. J Oral Pathol Med. 1994; 23: 65-69 Crossref PubMed Scopus (188) Google Scholar a potentially malignant condition of the mouth, pharynx, and oesophagus. Much effort has been expended in searching for the agents in areca nut which induce fibrosis. Recent evidence suggests upregulation of the copper-dependent extracellular enzyme lysyl oxidase by fibroblasts in oral submucous fibrosis is important, leading to excessive crosslinking and accumulation of collagen. 3 Ma RH Tsai CC Shieh TY Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan. J Oral Pathol Med. 1995; 24: 407-412 Crossref PubMed Scopus (81) Google Scholar
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