Acetylcarbocholine and acetylsilicocholine: Directly or indirectly acting cholinergic spasmogens?
1968; Oxford University Press; Volume: 20; Issue: 1 Linguagem: Inglês
10.1111/j.2042-7158.1968.tb09614.x
ISSN2042-7158
AutoresP.Th. Henderson, E. J. Ariëns, B W J Ellenbroek, A. M. Simonis,
Tópico(s)Enzyme function and inhibition
ResumoAbstract The cholinergic and anticholinergic actions of nitrogen-free isosteres of acetylcholine and benzilylcholine are described. Esters of two kinds of choline analogues, carbocholine and silicocholine, were used. The spasmogenic activity of acetylcarbocholine and acetylsilicocholine on the guinea-pig ileum was identified as an indirect cholinergic action, in contrast to the direct cholinergic action of furtrethonium and the mainly non-cholinergic action of barium ions. In addition to this indirect cholinergic action, both esters show a weak anticholinergic and a weak noncompetitive “papaverine-like” spasmolytic activity. The corresponding benzilyl esters, although without an onium group, are relatively potent anticholinergic compounds.
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