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Highly Enantioselective Construction of Quaternary Stereocenters on β‐Keto Esters by Phase‐Transfer Catalytic Asymmetric Alkylation and Michael Reaction

2003; Wiley; Volume: 42; Issue: 32 Linguagem: Inglês

10.1002/anie.200351469

1521-3773

Takashi Ooi, Takashi Miki, Mika Taniguchi, Misato Shiraishi, Mifune Takeuchi, Keiji Maruoka,

Advanced Synthetic Organic Chemistry

The designer ammonium salt (S,S)-1 catalyzes highly enantioselective phase-transfer alkylation and Michael reaction of β-keto esters. This approach provides a reliable route for the asymmetric synthesis of polyfunctionalized compounds having chiral quaternary carbon atoms. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51469_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.