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Constituintes químicos de Parmotrema lichexanthonicum Eliasaro & Adler: isolamento, modificações estruturais e avaliação das atividades antibiótica e citotóxica

2009; Brazilian Chemical Society; Volume: 32; Issue: 1 Linguagem: Inglês

10.1590/s0100-40422009000100003

ISSN

1678-7064

Autores

Ana Camila Micheletti, Adilson Beatriz, Dênis Pires de Lima, N Honda, Cláudia Pessoa, Manoel Odorico de Moraes, Letícia V. Costa‐Lotufo, Hemerson Iury Ferreira Magalhães, Nádia Cristina Pereira Carvalho,

Tópico(s)

Cancer Treatment and Pharmacology

Resumo

ANTIBIOTIC AND CYTOTOXIC ACTIVITIES.From the lichen Parmotrema lichexantonicum were isolated the depsidone salazinic acid, the xanthone lichexanthone, and the depside atranorin.The two major compounds, salazinic acid and lichexanthone, were selected for structure modifications.Salazinic acid afforded O-alkyl salazinic acids, some of them potentially cytotoxic against tumor cell lines (HCT-8, SF-295 and MDA/ MB -435).From lichexanthone were obtained norlichexanthone, 3-O-methylnorlichexanthone, 3-O-methyl-6-O-prenylnorlichexanthone, 3,6-di-O-prenyl-norlichexanthone, 3,6-bis[(3,3-dimethyloxyran-2-il)methoxy]-1-hydroxy-8-methyl-9H-xanten-9-one and 3,6-bis[3-(dimethylamine)propoxy]-1-hydroxy-8-methyl-9H-xanten-9-one.The last compound was the most active against S. aureus.

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