Portal de Periódicos da CAPES

Malignant transformation and life expectancy in monoclonal gammopathy of undetermined significance

1992; Wiley; Volume: 81; Issue: 3 Linguagem: Inglês

10.1111/j.1365-2141.1992.tb08245.x

1365-2141

Joan Bladé, Armando López‐Guillermo, C Rozmán, Francisco Cervantes, Camino Salgado, Josep‐Lluis Aguilar, Joan‐Lluís Vives Corrons, Emili Montserrat,

Chronic Lymphocytic Leukemia Research

The actuarial probability of malignant transformation and the impact on expected survival were analysed in a series of 128 persons diagnosed with monoclonal gammopathy of undetermined significance (MGUS) over a 20‐year period. At a median follow‐up of 56 months the M‐component remains stable in 101 patients (78·9%), 14 patients (10·9%) have died from non‐related disorders and 13 (10·2%) have developed malignant transformation of MGUS (multiple myeloma, 10; primary amyloidosis, two; Waldenström's macroglobulinaemia, one). The actuarial probability of malignant transformation at 5 and 10 years was 8·5% and 19·2%, respectively. When different presenting features were analysed for predictive value of the malignant transformation, the IgA type of MGUS was the only variable associated with a higher probability of such an event ( P <0·025). Although no significant difference was observed between the survival probability of persons with MGUS and that of the control population, the development of malignant transformation was associated with a shorter survival ( P <0·001).