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Retention of Neohydrin-Hg 203 as Determined with a Total-Body Scintillation Counter

1962; Radiological Society of North America; Volume: 78; Issue: 6 Linguagem: Inglês

10.1148/78.6.970

1527-1315

Robert H. Greenlaw, Merton A. Quaife,

Boron Compounds in Chemistry

HomeRadiologyVol. 78, No. 6 PreviousNext ArticlesRetention of Neohydrin-Hg203 as Determined with a Total-Body Scintillation CounterRobert H. Greenlaw22, Capt. Merton Quaife33Robert H. Greenlaw22, Capt. Merton Quaife33Author Affiliations American Cancer Society Advanced Clinical Fellow in Radiation Therapy.Graduate Fellow, Defense Atomic Support Agency.Robert H. Greenlaw22Capt. Merton Quaife33Published Online:Jun 1 1962https://doi.org/10.1148/78.6.970MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In AbstractAs radioisotopes are coming to hold an increasingly important position in clinical medicine, new ways of utilizing them and new labeled compounds are being sought by many groups of workers.If one reviews the physical characteristics of the various nuclides, radiomercury, Hg203, is found to possess some very desirable features. In particular, it has a single, rather weak gamma emission (280 kev) and enables good resolution when multihole focusing collimator and gamma spectrometry are used. Blau and Bender have used radiomercury-labeled Neohydrin in brain tumor localization with considerable success (1), and McAfee and Wagner (2) have reported promising studies with the same tracer for kidney scanning.Following the report of these latter writers, we started kidney scanning, finding excellent differential concentration of the isotope in the kidneys. Initially, data concerning the effective half-life of the tracer had been accepted as reported by McAfee. This matter was re-considered, however, after substantial residual activity was found at three days when kidney background had been measured prior to a radiorenogram. If excretion had proceeded at the rate reported, essentially no activity above background should have been present. The occurrence of residual renal activity prompted us to measure, sequentially, the persistence of labeled Neohydrin in human subjects. This report presents the results of that study.MATERIALS AND METHODSNeohydrin is Lakeside Laboratories'4 brand name for 3-chloromercuri-2-methoxy-propylurea. This drug is a well established organic mercurial diuretic which in clinical practice is administered chiefly by the oral route. The pharmacologic activity of this agent has been studied and is reported in standard pharmacology texts. With therapeutic doses of Neohydrin injected intravenously, 63 to 96 per cent of the dose is recovered in the urine within twenty-four hours.Of the twenty-two isotopes of mercury, six are stable and occur naturally. Thirteen of the sixteen radioactive isotopes of this element have half-lives considerably less than twenty-four hours. Only one isotope, Hg203, is worthy of consideration for clinical application. This has a half-life variously reported from forty-three and a half to forty-seven and nine-tenths days. It may be created by: Hg(n, γ), Hg(α, p), and T1 (n, p) reactions. The first of these is used in the commercial production of the isotope. The decay scheme is so well established it has been recommended as a standard for measuring photopeak efficiency in scintillation spectrometers. It is reproduced in Figure 1.Shielding and collimating the gamma emission from Hg203 is less of a problem than with I131 and Au198. The half-value layer in lead is 1.5 mm. In other words, a shield of 1 cm. of lead reduces the intensity to approximately 1 per cent.The labeled Neohydrin was supplied by E. R. Squibb and Abbott Radiopharmaceutical Companies. It was synthesized with previously activated mercury. Paper chromatography and chemical analysis of tracer Neohydrin from the two sources is being accomplished. Preliminary results show not more than 2 per cent as inorganic mercury and not labeled Neohydrin. The tracer has been supplied with the following specific activities and concentration:The intravenous dose given to the subjects in this study was 1 to 3 μc of activity. Doses of several hundred microcuries have been used by others for various diagnostic procedures.Article HistoryPublished in print: June 1962 FiguresReferencesRelatedDetailsCited ByNon-invasive radionuclide imaging of trace metal trafficking in health and disease: “PET metallomics”GeorgeFirth, Julia E.Blower, Joanna J.Bartnicka, AishwaryaMishra, Aidan M.Michaels, AlexRigby, AfnanDarwesh, FahadAl-Salemee, Philip J.Blower2022 | RSC Chemical Biology, Vol. 3, No. 5Metabolic data for mercury1980 | Annals of the ICRP, Vol. 4, No. 3-4Radioisotope in Geburtshilfe und GynäkologieH.Janisch, S.Leodolter1977Mit Radioquecksilber markierte Nuklearpharmaka. 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