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New Developments in Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) and Mismatch Repair Gene Testing

2006; Elsevier BV; Volume: 130; Issue: 2 Linguagem: Inglês

10.1053/j.gastro.2006.01.031

1528-0012

Stephen B. Gruber,

Colorectal Cancer Treatments and Studies

Genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC), or what is now more appropriately known as Lynch syndrome, has become the standard of care for patients with features suggestive of this syndrome and their at-risk relatives.1–5 Lynch syndrome is an autosomal dominant syndrome characterized by high risk of cancers of the colon and rectum, endometrium, stomach, small intestine, hepatobiliary system, upper ureteral tract, ovary, and rarely the brain.6–8 This review will highlight recent advances in the clinical recognition and genetic testing of Lynch syndrome.