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Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass

2008; Oxford University Press; Volume: 93; Issue: 11 Linguagem: Inglês

10.1210/jc.2007-2561

1945-7197

Anders R. Nielsen, Pernille Højman, Christian Erikstrup, Christian P. Fischer, Peter Plomgaard, Rémi Mounier, Ole Hartvig Mortensen, Christa Broholm, Sarah Taudorf, Rikke Krogh‐Madsen, Birgitte Lindegaard, Anne Marie Winther Petersen, Julie Gehl, Bente Klarlund Pedersen,

Adipose Tissue and Metabolism

IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass.The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice.In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P<0.05), trunk fat mass (P<0.01), and percent fat mass (P<0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass.Our results indicate that IL-15 may be a regulator of trunk fat mass.