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Artigo Revisado por pares
BIBTEX RIS

An Additional Coordination Group Leads to Extremely Efficient Chiral Iridium Catalysts for Asymmetric Hydrogenation of Ketones

2011; Wiley; Volume: 50; Issue: 32 Linguagem: Inglês

10.1002/anie.201102710

ISSN

1521-3773

Autores

Jian‐Hua Xie, Xiaoyan Liu, Jian‐Bo Xie, Lixin Wang, Qi‐Lin Zhou,

Tópico(s)

Asymmetric Synthesis and Catalysis

Resumo

What a turnover! An efficient chiral iridium catalyst that bears a tridentate spiro aminophosphine ligand catalyzes the asymmetric hydrogenation of ketones with excellent enantioselectivities (up to 99.9 % ee) and extremely high turnover numbers (TONs; as high as 4 550 000).

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