Portal de Periódicos da CAPES

Lysine sulfonamides as novel HIV-protease inhibitors: Nε-Acyl aromatic α-amino acids

2006; Elsevier BV; Volume: 16; Issue: 13 Linguagem: Inglês

10.1016/j.bmcl.2006.04.011

1464-3405

Brent R. Stranix, Jean-François Lavallée, Guy Sévigny, Jocelyn Yelle, Valérie Perron, Nicholas LeBerre, Dominik Herbart, Jinzi J. Wu,

HIV/AIDS Research and Interventions

A series of lysine sulfonamide analogues bearing Nε-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses.