Distribution of GABA and glycine receptors on bipolar and ganglion cells in the mammalian retina
2000; Wiley; Volume: 50; Issue: 2 Linguagem: Inglês
10.1002/1097-0029(20000715)50
ISSN1097-0029
Autores Tópico(s)Photoreceptor and optogenetics research
ResumoMicroscopy Research and TechniqueVolume 50, Issue 2 p. 130-140 Topical PaperFree Access Distribution of GABA and glycine receptors on bipolar and ganglion cells in the mammalian retina Ulrike Grünert, Corresponding Author Ulrike Grünert gruenert@physiol.usyd.edu.au Department of Physiology and Institute for Biomedical Research, The University of Sydney, N.S.W., AustraliaDept. Physiology F13, The University of Sydney, N.S.W. 2006, AustraliaSearch for more papers by this author Ulrike Grünert, Corresponding Author Ulrike Grünert gruenert@physiol.usyd.edu.au Department of Physiology and Institute for Biomedical Research, The University of Sydney, N.S.W., AustraliaDept. Physiology F13, The University of Sydney, N.S.W. 2006, AustraliaSearch for more papers by this author First published: 06 July 2000 https://doi.org/10.1002/1097-0029(20000715)50:2 3.0.CO;2-ICitations: 38AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The amino acids GABA and glycine mediate synaptic transmission via specific neurotransmitter receptors. Molecular cloning studies have shown that there is a great diversity of GABA and glycine receptors. In the present article, the distribution of GABA and glycine receptors on identified bipolar and ganglion cell types in the mammalian retina is reviewed. Immunofluorescence obtained with antibodies against GABA and glycine receptors is punctate. Electron microscopy shows that the puncta represent a cluster of receptors at synaptic sites. Bipolar cell types were identified with immunohistochemical markers. Double immunofluorescence with subunit-specific antibodies was used to analyze the distribution of receptor clusters on bipolar axon terminals. The OFF cone bipolar cells seem to be dominated by glycinergic input, whereas the ON cone bipolar and rod bipolar cells are dominated by GABAergic input. Ganglion cells were intracellularly injected with Neurobiotin, visualized with Streptavidin coupled to FITC, and subsequently stained with subunit specific antibodies. 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