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The need for indispensable amino acids: The concept of the anabolic drive

1989; Wiley; Volume: 5; Issue: 2 Linguagem: Inglês

10.1002/dmr.5610050207

1099-0895

D. J. Millward, J. P. W. Rivers,

Pancreatic function and diabetes

Diabetes/Metabolism ReviewsVolume 5, Issue 2 p. 191-211 Protein and Amino Acid Metabolism The need for indispensable amino acids: The concept of the anabolic drive D. J. Millward, D. J. Millward Nutrition Research Unit, London School of Hygiene & Tropical Medicine, St Pancras Hospital, 4 St Pancras Way, London NW1 2PE, United KingdomSearch for more papers by this authorJ. P. W. Rivers, J. P. W. Rivers Nutrition Research Unit, London School of Hygiene & Tropical Medicine, St Pancras Hospital, 4 St Pancras Way, London NW1 2PE, United KingdomSearch for more papers by this author D. J. Millward, D. J. Millward Nutrition Research Unit, London School of Hygiene & Tropical Medicine, St Pancras Hospital, 4 St Pancras Way, London NW1 2PE, United KingdomSearch for more papers by this authorJ. P. W. Rivers, J. P. W. Rivers Nutrition Research Unit, London School of Hygiene & Tropical Medicine, St Pancras Hospital, 4 St Pancras Way, London NW1 2PE, United KingdomSearch for more papers by this author First published: March 1989 https://doi.org/10.1002/dmr.5610050207Citations: 37AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Weller LA, Calloway DH, and Margen S: Nitrogen balance of men fed amino acid mixtures based on Rose's requirements, egg white protein, and serum free amino acid patterns. J Nutr 101: 1499–1508, 1971. 2 Meguid MM, Matthews DE, Bier DM, et al.: Leucine kinetics at graded leucine intakes in young men. Am J Clin Nutr 43: 770–780, 1986. 3 Meguid MM, Matthews DE, Bier DM, et al.: Valine kinetics at graded valine intakes in young men. Am J Clin Nutr 43: 781–786, 1986. 4 Meredith CN, Wen Z-M, Bier DM, et al.: Lysine kinetics at graded lysine levels in young men. Am J Clin Nutr 43: 787–794, 1986. 5 Zhao X-h, Wen Z-M, Meredith CN, et al.: Threonine kinetics at graded threonine intakes in young men. Am J Clin Nutr 43: 795–802, 1986. 6 Millward DJ, and Rivers J: The nutritional role of indispensable amino acids and the metabolic basis for their requirements. Eur J Clin Nutr 42: 367–393, 1988. 7 FAO/WHO/UNU: Energy and protein requirements, report of a joint FAO/WHO/UNO meeting. In Technical Report Series. World Health Organization, Geneva 1985, No. 724. 8 Rennie MJ, Edwards RHT, Halliday D, et al.: Muscle protein synthesis measured by stable isotope techniques in man: The effects of feeding and fasting. Clin Sci 63: 519–523, 1982. 9 Bates PC, and Millward DJ: Changes in the relative rates of protein synthesis and degradation during muscle growth and atrophy. Biochem Soc Trans 6: 612–614, 1978. 10 Millward DJ: Human protein requirements: The physiological significance of changes in the rate of whole-body protein turnover. In Substrate and Energy Metabolism in Man, JS Garrow, and D Halliday, Eds. John Libbey, London, 1985, pp 135–144. 11 Garrel DR, Todd KS, Pugeat MM, et al.: Hormonal changes in normal men under marginally negative energy balance. Am J Clin Nutr 39: 930–936, 1984. 12 De Benoist B, Abdulrazzak Y, Brooke OG, et al.: The measurement of whole body protein turnover in the preterm infant with intragastric infusion of L-[1-13C]leucine and sampling of the urinary leucine pool. Clin Sci 66: 155–164, 1984. 13 Waterlow JC: Protein turnover in the whole animal. Invest Cell Pathol 3: 107–119, 1980. 14 Golden MHN, Waterlow JC, and Picou D: Protein turnover, synthesis and breakdown before and after recovery from protein-energy malnutrition. Clin Sci Mol Med 53: 473–477, 1977. 15 Millward DJ: Protein turnover in skeletal and cardiac muscle during normal growth and hypertrophy. In Degradative Processes in Heart and Skeletal Muscle, K Wildenthal, Ed. Elsevier/North Holland, Amsterdam, 1980, pp 161–199. 16 Baillie AGS, Matlin CA, and Garlick PJ: The effect of fasting and insulin infusion on muscle protein synthesis in immature and adult rats. Proc Nutr Soc, in press. 17 FAO/WHO: Energy and protein requirements. Report of a joint FAO/WHO ad hoc expert committee. In Technical Report Series. World Health Organization, Geneva, 1973, No. 522. 18 Rennie MJ, Edwards RHT, Krywawych S, et al.: Effect of exercise on protein turnover in man. Clin Sci 61: 627–639, 1981. 19 Pogson CI, Salter M, and Knowles RG: Regulation of hepatic aromatic amino acid metabolism. Biochem Soc Trans 14: 999–1001, 1986. 20 Block KP, Aftring RP, Mehard WB, et al.: Modulation of rat skeletal muscle branched-chain keto acid dehydrogenase in vivo. J Clin Invest 79: 1349–1358, 1987. 21 Rose WC: The amino acid requirements of adult man. Nutr Abs Revs 27: 631–647, 1957. 22 Golden M: The consequences of protein deficiency in man and its relationship to the features of kwashiorkor. In Nutritional Adaptation in Man, K Blaxter, and JC Waterlow, Eds. John Libbey, London, 1985 pp 169–188. 23 Clemens MJ, Pain VC, Wong S-T, et al.: Phosphorylation inhibits guanine nucleotide exchange on eukaryotic initiation factor 2. Nature 296: 93–95, 1983. 24 Harmon CS, Proud CG, and Pain VM: Effects of starvation, diabetes and acute insulin treatment on the regulation of polypeptide-chain initiation in rat skeletal muscle. Biochem J 223: 687–696, 1984. 25 Buse MG, Channa IR, Owens M, et al: Muscle protein synthesis: Regulation of a translational inhibitor. Am J Physiol 246: E510–E515, 1984. 26 Goldberg AL, Tischler M, DeMartino G, et al.: Hormonal regulation of protein degradation and synthesis in skeletal muscle. Fed Proc 39: 31–36, 1980. 27 Reeds PJ, Palmer RM, and Wahle KWJ: The role of metabolites of arachidonic acid in the physiology and pathophysiology of muscle protein metabolism. Biochem Soc Trans 15: 328–331, 1987. 28 Jefferson LS: Role of insulin in the regulation of protein synthesis. Diabetes 29: 487–496, 1980. 29 MacLennan PA, Brown RA, and Rennie MJ: A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle. Febs Lett 215: 187–191, 1987. 30 Garlick PJ, McNurlan MA, and Preedy VR: A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H]phenylalanine. Biochem J 192: 719–723, 1980. 31 Millward DJ, Garlick PJ, James WPT, et al.: Relationship between protein synthesis and RNA content in skeletal muscle. Nature 2412: 204–205, 1973. 32 Millward DJ, Garlick PJ, Nnanyelugo DO, et al.: The relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass. Biochem J 156: 185–188, 1976. 33 Jepson MM, Bates PC, and Millward DJ: The role of insulin and thyroid hormones in the regulation of muscle growth and protein turnover in response to dietary protein. B J Nutr 185–188, 1987. 34 Yahya ZAH, Tirapegui J, Bates PC, et al.: Dietary and hormonal influences on plasma IGF-1 levels in the rat. J Endocrin (suppl) 115: 71, 1987. 35 Prewett TEA, D'Ercole AJ, Switzer BR, et al.: Relationship of serum immunoreactive somatomedin-c to dietary protein and ee. J Nutr 112: 144–150, 1982. 36 Tischler ME, Desautels M, and Goldberg AL: Does leucine, leucyl tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle?. J Biol Chem 257: 1613–1621, 1982. 37 Mitch WE, and Clark AS: Specificity of the effects of leucine and its metabolites on protein degradation in skeletal muscle. Biochem J 222: 579–586, 1984. 38 McNurlan MA, Fern EB, and Garlick PJ: Failure of leucine to stimulate protein synthesis in vivo. Biochem J 204: 831–838, 1982. 39 Odedra B, Dalal SS, and Millward DJ: Muscle protein synthesis in the streptozotocin diabetic rat: A possible role for corticosterone in the insensitivity of insulin infusion in vivo. Biochem J 202: 363–368, 1982. 40 Millward DJ, Waterlow JC: Effect of nutrition on protein turnover in skeletal muscle. Fed Proc 37: 2283–2290, 1978. 41 Preedy VR, Garlick PJ: The response of muscle protein synthesis to nutrient intake in postabsorptive rats: the role of insulin and amino acids. Biosci Rep 6: 177–180, 1986. 42 Jepson MM, Broadbent P, Bates PC, et al.: The relationship between glutamine concentration and protein synthesis in rat skeletal muscle. Am J Physiol, 255, E166–E174. 43 Rennie MJ, Hundal H, Babij P, et al.: Characteristics of a glutamine carrier in skeletal muscle have important consequences for nitrogen loss in injury, infection and chronic disease. Lancet 50: 1008–1012, 1986. 44 Millward DJ, Bates PC, Brown JG, et al.: Protein degradation and the regulation of protein balance in muscle. In Protein Degradation in Health and Disease, Ciba Foundation Symposium 75 Excerpta Medica, Oxford, 1980, pp 307–330. 45 MacLennan PA, Brown RA, and Rennie MJ: A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle. Febs Lett 215: 187–191, 1987. 46 Poso AR, and Mortimore GE: Amino acid control of hepatic protein degradation: Novel requirement for alanine. In Intracellular Protein Catabolism, EA Khairallah, JS Bond, and JWC Bird, Eds. Alan R. Liss, New York, 1985, pp 427–436. 47 Smith RJ: Regulation of protein degradation in differentiated skeletal muscle cells in monolayer culture. In Intracellular Protein Catabolism, EA Khairallah, JS Bond, and JWC Bird, Eds. Alan R. Liss, New York, 1985, pp 633–635. 48 Flaim KE, Li JB, and Jefferson LS: Effects of thyroxine on protein turnover in rat skeletal muscle. Am J Physiol 4: E231–E236, 1978. 49 Tischler ME: Hormonal regulation of protein degradation in skeletal and cardiac muscle. Life Sci 28: 2569–2576, 1981. 50 Millward DJ, Bates PC, Coyer P, et al.: The effect of dietary energy and protein on growth as studied in animal models. In Energy and Protein Needs During Infancy, SJ Foman, and W Heird, Eds. Academic Press, New York, 1986, pp 127–156. 51 Millward DJ: Physiological regulation of proteolysis in muscle. Biochem Soc Trans 13: 1023–1026, 1985. 52 Millward DJ, Bates PC, Brown JG, et al.: Role of thyroid, insulin and corticosteroid hormones in the physiological regulation of proteolysis in muscle. Prog Clin Biol Res 180: 531–542, 1985. 53 Fajans SS, and Floyd JC Jr.: Stimulation of islet cell secretion by nutrients and by gastroentestinal hormones released during digestion. In Handbook of Physiology. Section 7: Endocrinology. American Physiological Society, Washington, D.C., 1972, p 473. 54 Berthoud HR: The relative contribution of the nervous system, hormones, and metabolites to the total insulin response during a meal in the rat. Metabolism 33: 18–25, 1984. 55 Okajima F, and Ui M: Adrenergic modulation of insulin secretion in vivo dependent on thyroid states. Am J Physiol 234: E106–E111, 1978. 56 Silva JE, and Larsen PR: Potential of brown adipose tissue type II thyroxine 5′-deiodinase as a local and systemic source of triiodothyronine in rats. J Clin Invest 76: 2296–2305, 1985. 57 Sato K, and Robbins J: Thyroid hormone metabolism in primary cultured rat hepatocytes. J Clin Invest 68: 475–483, 1981. 58 Gavin LA, and Moeller M: The mechanism of recovery of hepatic T4–5′-Deiodinase during glucose-refeeding: Role of glucagon and insulin. Metabolism 32: 543–551, 1983. 59 Millward DJ, Odedra B, and Bates PC: Role of insulin, corticosterone and other factors in the acute recovery of muscle protein synthesis on refeeding food-deprived rats. Biochem J 216: 583–587, 1983. 60 Nair KS, Ford GC, and Halliday D: Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients. Metabolism 36: 491–495, 1987. 61 Hambraeus L, Bilmazes C, Dippel C, et al.: Regulatory role of dietary leucine on plasma branched-chain amino acid levels in young men. J Nutr 106: 230–240, 1976. 62 Palmer RM: Protein synthesis and degradation in isolated rabbit muscle. In The Role of Prostaglandins in the Hormonal Control of Protein Turnover, Ph.D. thesis, University of Aberdeen, 1987. 63 Tata JR: Growth and developmental action of thyroid hormones at the cellular level. In Handbook of Physiology. Section 7. Vol. 3, MA Greer, and DH Soloman, Eds., American Physiological Society, Washington, D.C. 1974, Vol. 3, Sect. 7, pp 469–478. 64 Brown JG, and Millward DJ: Dose response of protein turnover in rat skeletal muscle to triiodothyronine treatment. Biochim Biophys Acta 757: 182–190, 1983. 65 Millward DJ, Bates PC, Brown JG, et al.: Protein turnover and the regulation of growth. In Nitrogen Metabolism in Man, JC Waterlow, and JML Stephen, Eds. Applied Science Publishers, London, 1981, pp 409–418. 66 Brown JG, Bates PC, Holliday MA, et al.: Thyroid hormones and muscle protein turnover: The effect of thyroid hormone deficiency and replacement in thyroidectomised and hypophysectomised rats. Biochem J 194: 771–782, 1981. 67 Brown JG, van Bueren J, and Millward DJ: The effect of tri-iodothyronine administration on protein synthesis in the diabetic rat. Biochem J 214: 637–640, 1983. 68 Busch WM, and Van Wijk JJ: Triiodothyronine stimulates cartilage growth and maturation by different mechanisms. Am J Physiol 252: E176–E182, 1987. 69 Mathews RW, Oronsky A, and Haschemeyer AEV: Effect of thyroid hormone on polypeptide chain assembly kinetics in liver protein synthesis in vivo. J Biol Chem 248: 1320–1333, 1973. 70 Mathews RW, and Haschemeyer AEV: Temperature dependency of protein synthesis in toadfish liver in vivo. Comp Biochem Physiol 61B: 479–484, 1978. 71 Millward DJ, Brown JG, and van Beuren J: Influence of plasma concentrations of T3 on the acute increases in insulin and muscle protein synthesis in the refed fasted rat. J. Endocr. 118, 417–422, 1988. 72 Burman KD, Wartofsky L, Dinterman RE, et al.: Effect of T3 and reverse T3 administration on muscle protein catabolism during fasting as measured by 3-methylhistidine excretion. Metabolism 28: 805–813, 1979. 73 DeMartino GN, and Goldberg AL: Thyroid hormones control lysosomal enzyme activities in liver and skeletal muscle. Proc Natl Acad Sci USA 75: 1369–1373, 1978. 74 Zeman RJ, Bernstein PL, Ludemann R, et al.: Regulation of Ca2+-dependent protein turnover in skeletal muscle by thyroxine. Biochem J 240: 269–272, 1986. 75 Bates PC, Holder AT, and Millward DJ: The effect of thyroxine and human growth hormone on muscle and bone growth in the Snell dwarf mouse. J Physiol 380: 78P, 1986. 76 Hart IC, and Johnsson ID: Growth hormone and growth in meat producing animals. In Control and Regulation of Animal Growth, PJ Buttery, NB Haynes, and DB Lindsay, Eds. Butterworths, London, 1986, pp 135–159. 77 Pell JM, and Bates PC: Collagen and non-collagen protein turnover in skeletal muscle of growth hormone-treated lambs. J Endocrinol 115: R1–R4, 1987. 78 Froesch ER, and Zapf J: Insulin-like growth factors and insulin: Comparative aspects. Diabetologia 28: 485–493, 1985. 79 Zapf J, and Froesch ER: Insulin-like growth factors, somatomedins: Structure, secretion, biological actions and physiological role. Hormone Res 24: 121–130, 1986. 80 Ashworth A, and Millward DJ: Catch-up growth in children. Nut Revs 44: 157–163, 1986. 81 Dodson MV, Allen RE, and Hossner KL: Ovine somatomedin, multiplication-stimulating activity, and insulin promote skeletal muscle satellite cell proliferation in vitro. Endocrinology 117: 2357, 1985. 82 Stock MJ, and Rothwell NJ: Effects of beta-adrenergic agonists on metabolism and body composition. In Control and Manipulation of Animal Growth, PJ Buttery, DB Lindsay, and NB Haynes, Eds. Butterworths, London, 1986, pp 249–257. 83 Coyer PA, Rivers JPW, and Millward DJ: The effect of dietary protein and energy restriction on heat production and growth costs in the young rat. Br J Nutr 58: 73–85, 1987. 84 Giugliano R, and Millward DJ: Muscle protein turnover in the severely zinc-deficient rat. Proc. Nutr Soc 43: 77a, 1984. 85 Giugliano R, and Millward DJ: The effects of severe zinc deficiency on protein turnover in muscle and thymus. Br J Nutr 57: 139–155, 1987. 86 Bolze MS, Reeves RD, Lindbeck FE, et al.: Influence of zinc on growth, somatomedin, and glycosaminoglycan metabolism in rats. Am J Physiol 252: E21–E26, 1987. 87 Clugston GA, and Garlick PJ: The response of protein and energy metabolism to food intake in lean and obese man. Hum Nutr Clin Nutr 36C: 57–70, 1982. 88 Yahya ZAH, Bates PC, Buchanan C, et al: IGF-1 concentrations in protein deficient rat plasma and tissues. Biochem Soc Trans, 16: 624–625, 1988. Citing Literature Volume5, Issue2March 1989Pages 191-211 ReferencesRelatedInformation