Produção Nacional
Revisado por pares
Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load
2011; Elsevier BV; Volume: 52; Issue: 3 Linguagem: Inglês
10.1016/j.jcv.2011.07.016
ISSN1873-5967
AutoresCristina Castro-Lima Vargens, Maria Fernanda Rios Grassi, Ney Boa‐Sorte, Regina Helena Rathsam-Pinheiro, Viviana Nilla Olavarria, Ramon de Almeida Kruschewsky, Bernardo Galvão‐Castro,
Tópico(s)Vector-Borne Animal Diseases
ResumoA high HTLV-1 proviral load is found in HTLV-1-associated diseases, mainly HAM/TSP. However, the association between proviral load and keratoconjunctivitis sicca (KCS) has not been well established. To verify the association between KCS and HTLV-1 proviral load. 104 HTLV-1 infected patients (51 asymptomatic and 52 with HAM/TSP) from the HTLV reference center in Salvador, Brazil were followed from June 2008 to May 2010. Evaluation of tear secretion was performed by BUT (break-up time), Rose Bengal and Schirmer I tests. The diagnosis of KCS was based upon the presence of symptoms and when at least two of three tests were positive. HTLV-1 proviral load was determined using real-time PCR. The prevalence of KCS was 44.2%. KCS was more frequent among HAM/TSP patients (p = 0.022). Patients with KCS had higher proviral load (mean 134,672 ± 150,393 copies/106 PBMC) than patients without the disease (mean 66,880 ± 109,525 copies/106 PBMC) (p = 0.001). HTLV-1 proviral load > 100,000 copies/106 PBMC increased significantly the risk of developing KCS (OR = 4.05 and 95% CI = 1.40–11.76). After age > 45 years and HAM/TSP status were excluded in stepway reward analysis, the variables PVL > 100,000 (OR = 4.77 and 95% CI = 1.83–12.44) still remained statistically significant. HTLV-1 proviral loads are higher in patients with KCS and may represent a relevant biological marker of disease.
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