Influence of peptides on reduced response of rats to electric footshock after acute administration of morphine
1975; Elsevier BV; Volume: 33; Issue: 1 Linguagem: Inglês
10.1016/0014-2999(75)90143-0
ISSN1879-0712
AutoresWillem Hendrik Gispen, Tjeerd B. Van Wimersma Greidanus, Cheryl Waters-Ezrin, Emery Zimmermann, William A. Krivoy, D. de Wied,
Tópico(s)Neuroendocrine regulation and behavior
ResumoAcute treatment of rats with morphine (10 mg/kg) resulted in a marked reduction of motor response to inescapable electric footshock (EFS). Nalorphine (2 mg/kg) antagonized this action of morphine. Pretreatment with synthetic ACTH 1–24 (10 IU) 60 min prior to testing also inhibited this morphine-induced reduction, whereas other ACTH-like peptides, lacking corticotrophic activity, were ineffective. ACTH 1–24 had no effect on the response of adrenalectomized rats to EFS after morphine. In intact rats dexamethasone pretreatment 4 hr prior to testing also antagonized the action of morphine on EFS. Taken together these findings suggest that ACTH 1–24 interferes with the antinociceptive action of morphine and that the integrity of the adrenal is essential for demontration of this antagonism.
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