Produção Nacional
Revisado por pares
Elimination of Influences of the ACTN3 R577X Variant on Oxygen Uptake by Endurance Training in Healthy Individuals
2015; Human Kinetics; Volume: 10; Issue: 5 Linguagem: Inglês
10.1123/ijspp.2014-0205
ISSN1555-0273
AutoresMichelle S.M. Silva, Wladimir Bolani, Cléber R. Alves, Diogo Biagi, José R. Lemos, Jeferson L. da Silva, Patrícia Abrão de Oliveira, Guilherme B. Alves, Edilamar Menezes de Oliveira, Carlos Eduardo Negrão, José Eduardo Krieger, Rodrigo Gonçalves Dias, Alexandre C. Pereira,
Tópico(s)Muscle metabolism and nutrition
ResumoAim: To study the relationship between the ACTN3 R577X polymorphism and oxygen uptake (VO 2 ) before and after exercise training. Methods: Police recruits (N = 206, 25 ± 4 y) with RR (n = 75), RX (n = 97), and XX (n = 33) genotypes were selected. After baseline measures, they underwent 18 wk of running endurance training. Peak VO 2 was obtained by cardiopulmonary exercise testing. Results: Baseline body weight was not different among genotypes. At baseline, XX individuals displayed higher VO 2 at anaerobic threshold, respiratory compensation point, and exercise peak than did RR individuals ( P < .003). Endurance training significantly increased VO 2 at anaerobic threshold, respiratory compensation point, and exercise peak ( P < 2 × 10 −6 ), but the differences between XX and RR were no longer observed. Only relative peak VO 2 exercise remained higher in XX than in RR genotype ( P = .04). In contrast, the increase in relative peak VO 2 was greater in RR than in XX individuals (12% vs 6%; P = .02). Conclusion: ACTN3 R577X polymorphism is associated with VO 2 . XX individuals have greater aerobic capacity. Endurance training eliminates differences in peak VO 2 between XX and RR individuals. These findings suggest a ceiling-effect phenomenon, and, perhaps, trained individuals may not constitute an adequate population to explain associations between phenotypic variability and gene variations.
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