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Predictors of long-term survival in dogs with high-grade multicentric lymphoma

2011; American Veterinary Medical Association; Volume: 238; Issue: 4 Linguagem: Inglês

10.2460/javma.238.4.480

1943-569X

Laura Marconato, D. Stefanello, Paola Valenti, Ugo Bonfanti, S. Comazzi, Paola Roccabianca, M. Caniatti, Giorgio Romanelli, Federico Massari, Eric Zini,

Cancer Genomics and Diagnostics

Abstract Objective —To determine factors predicting survival in dogs with high-grade multicentric lymphoma. Design —Retrospective cohort study. Animals —127 dogs with high-grade multicentric lymphoma evaluated at 4 veterinary hospitals from 2000 to 2009. Procedures —Records were reviewed to identify dogs with completely staged high-grade multicentric lymphoma treated with chemotherapy. Data collected included signalment, history, hematologic findings, tumor characteristics, treatment, and outcome. Long-term survival was defined as surviving > 2 years after diagnosis. Variables were analyzed for associations with dogs living > 2 years. Results —Among the 127 enrolled dogs, 13 (10%) survived > 2 years with a median survival time of 914 days (range, 740 to 2,058 days). Survival rates at 3, 4, and 5 years were 4%, 3%, and 1 %, respectively. At diagnosis, 11 of the 13 long-term survivors had a body weight ≥ 10 kg, PCV ≥ 35%, absence of ionized hypercalcemia, centroblastic lymphoma, immunophenotype B, absence of bone marrow involvement, and lymphoma stages I through IV and were not previously treated with corticosteroids. The same combination of factors was present in 26 of 114 (23%) dogs surviving ≤ 2 years, yielding a negative predictive value of 97.8% for long-term survivors. Four of the 6 long-term survivors that died during the study died of another cancer; 3 of them had osteosarcoma. Conclusions and Clinical Relevance —Absence of the aforementioned combination of variables at diagnosis may help identify dogs with lymphoma that will not survive > 2 years. Other types of neoplasia, in particular osteosarcoma, may develop in long-term–surviving dogs.