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Antipyretic Efficacy and Safety of Ibuprofen and Acetaminophen in Children

2003; SAGE Publishing; Volume: 38; Issue: 1 Linguagem: Inglês

10.1345/aph.1c391

1542-6270

Ran D. Goldman, Karen Ko, Lauren Linett, Dennis Scolnik,

Hematological disorders and diagnostics

OBJECTIVE: To evaluate the antipyretic effects and safety of ibuprofen compared with acetaminophen in febrile children. DATA SOURCES: Searches of MEDLINE (1966–November 2003) and EMBASE (1988–November 2003) were conducted using the terms ibuprofen and acetaminophen. Bibliographies of selected articles were reviewed. DATA SYNTHESIS: Ibuprofen was significantly more effective than acetaminophen in reducing fever after a single dose. Ibuprofen was found to be more effective after 6 hours, but not after a longer period of time. Studies with multiple doses have also failed to show that one drug is better than the other. CONCLUSIONS: The efficacy and effectiveness of acetaminophen and ibuprofen in their recommended dosages are similar, with slightly more beneficial effects shown with ibuprofen.