Evolution of MRI changes and development of bilateral hippocampal sclerosis during long lasting generalised status epilepticus
2004; BMJ; Volume: 75; Issue: 6 Linguagem: Inglês
10.1136/jnnp.2003.015354
ISSN1468-330X
Autores Tópico(s)Neuroscience and Neuropharmacology Research
ResumoThis report describes a previously healthy 28 year old patient with a 5 month period of intractable generalised status epilepticus (SE) of unknown aetiology with fatal outcome. Repeated magnetic resonance imaging (MRI) showed no pre-existing abnormality, but did show progressive cortical and hippocampal atrophy and T2 hyperintensity in both hippocampal formations, suggestive of progressive tissue damage. Post-mortem histopathological analysis revealed substantial neuronal cell loss including CA1 and CA4 sectors of the hippocampus compatible with bilateral hippocampal sclerosis. There was no evidence of systemic complications including arterial hypotension and hypoxia, hypoglycaemia, hyperpyrexia, or other confounding factors to account for these findings. This case provides further evidence of SE induced hippocampal damage in humans.
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