Portal de Periódicos da CAPES

Total Synthesis of the Polycyclic Fungal Metabolite (±)‐Communesin F

2010; Wiley; Volume: 49; Issue: 11 Linguagem: Inglês

10.1002/anie.200906818

1521-3773

Peng Liu, Jae Hong Seo, Steven M. Weinreb,

Fungal Biology and Applications

What the Heck: The heptacyclic fungal alkaloid communesin F was the target of a total synthesis featuring a rare example of an intramolecular Heck cyclization of a tetrasubstituted alkene, a reductive cyclization of an N-Boc aniline, a stereoselective C allylation of a lactam, and an azide reduction/N-Boc-δ-lactam ring opening sequence (see scheme, BOM=benzyloxymethyl).