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The epsilon subunit confers fast channel gating on multiple classes of acetylcholine receptors

1993; Society for Neuroscience; Volume: 13; Issue: 2 Linguagem: Inglês

10.1523/jneurosci.13-02-00605.1993

1529-2401

Patricia Camacho, Yi Liu, Gail Mandel, Paul Brehm,

Receptor Mechanisms and Signaling

During vertebrate skeletal muscle development, multiple forms of long- open-time (slow-type) ACh receptor channels are replaced by at least two different types of short-open-time (fast-type) ACh receptors. Expression of ACh receptors in Xenopus oocytes indicates that the substitution of an epsilon subunit for a gamma subunit may account for both types of fast-gated channel types in adult muscle. Unlike the various forms of the embryonic receptor, in which functional diversity is achieved through alterations in subunit composition, the two major fast-gated forms expressed in oocytes have identical subunit composition. These findings provide a structural basis for both types of short-open-time ACh receptor types found in adult muscle.