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Enantioselective cyclization of enamide-ynes and application to the synthesis of the kopsifoline core

2013; Elsevier BV; Volume: 69; Issue: 27-28 Linguagem: Inglês

10.1016/j.tet.2013.02.091

1464-5416

Britton K. Corkey, Stephen T. Heller, Yiming Wang, F. Dean Toste,

Marine Sponges and Natural Products

We report the palladium-catalyzed enantioselective cyclization of 1,6-enamidynes to form spirocyclic ring systems. We applied this methodology to the concise synthesis of the skeletal core of the kopsifoline alkaloids.