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Chemical Structures of Excoecarins A, B and C: Three New Labdane-Type Diterpenes from Wood, Excoecaria agallocha.

1996; Pharmaceutical Society of Japan; Volume: 44; Issue: 11 Linguagem: Inglês

10.1248/cpb.44.2100

1347-5223

Tenji Konishi, Shiu Kiyosawa, Takao Konoshima, Yasuhiro Fujiwara,

Natural Compounds in Disease Treatment

Three new diterpenes, excoecarins A (2), B (3) and C (4) have been isolated from the wood of Excoecaria agallocha LINN. The structures of excoecarins A, B and C were established as (13R, 14R)-ent-8α, 13;14, 15-diepoxy-13-epi-labda-3-one (2), (13R, 14S)-ent-8α, 13;14, 15-diepoxy-13-epi-labda-3-one (3), (13R, 14R)-ent-8α, 13;14, 15-diepoxy-13-epi-labda-3β-ol (4), respectively, on the basis of spectroscopic data and chemical evidence.