A Drug–Perfluorocarbon Nanoemulsion with an Ultrathin Silica Coating for the Synergistic Effect of Chemotherapy and Ablation by High‐Intensity Focused Ultrasound
2014; Volume: 26; Issue: 43 Linguagem: Inglês
10.1002/adma.201402969
ISSN1521-4095
AutoresMing Ma, Hui‐Xiong Xu, Hangrong Chen, Xiaoqing Jia, Kun Zhang, Qi Wang, Shu-Guang Zheng, Rong Wu, Minghua Yao, Xiaojun Cai, Faqi Li, Jianlin Shi,
Tópico(s)Ultrasound Imaging and Elastography
ResumoThe synergistic effect of chemotherapy and ablation using high-intensity focused ultrasound (HIFU) is realized with a newly developed drug-delivery system. The system comprises an ultrathin silica shell surrounding a poly(lactic-co-glycolic acid) nanoemulsion core containing the drug (CPT) and a perfluorocarbon (PFOB). This nanosystem presents many advantages in drug delivery, such as excellent structural stability, high drug-loading capacity, and rapid HIFU-mediated drug release. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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