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Fast multidimensional localized parallel NMR spectroscopy for the analysis of samples

2010; Wiley; Volume: 48; Issue: 10 Linguagem: Inglês

10.1002/mrc.2659

1097-458X

Marino Vega-Vázquez, Juan Carlos Cobas, Manuel Martín‐Pastor,

Advanced MRI Techniques and Applications

A parallel localized spectroscopy (PALSY) method is presented to speed up the acquisition of multidimensional NMR (nD) spectra. The sample is virtually divided into a discrete number of nonoverlapping slices that relax independently during consecutive scans of the experiment, affording a substantial reduction in the interscan relaxation delay and the total experiment time. PALSY was tested for the acquisition of three experiments 2D COSY, 2D DQF-COSY and 2D TQF-COSY in parallel, affording a time-saving factor of 3-4. Some unique advantages are that the achievable resolution in any dimension is not compromised in any way: it uses conventional NMR data processing, it is not prone to generate spectral artifacts, and once calibrated, it can be used routinely with these and other combinations of NMR spectra.