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Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation

2014; Cell Press; Volume: 20; Issue: 2 Linguagem: Inglês

10.1016/j.cmet.2014.07.014

1932-7420

Stéphan Hardivillé, Gerald W. Hart,

Carbohydrate Chemistry and Synthesis

The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc’s regulation of cell physiology. The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc’s regulation of cell physiology.