Portal de Periódicos da CAPES

Outcomes of transplantation in children with primary hepatic malignancy

2007; Wiley; Volume: 11; Issue: 6 Linguagem: Inglês

10.1111/j.1399-3046.2007.00751.x

1399-3046

Mona Beaunoyer, Jason M. Vanatta, Makoto Ogihara, Debra Strichartz, Gary V. Dahl, William E. Berquist, Ricardo Castillo, Kenneth L. Cox, Carlos O. Esquivel,

Liver Disease Diagnosis and Treatment

Abstract: HBL and HCC are the most common hepatic malignancies in children. The role of OLT in children with HCC is still a matter of debate. The aim of this study was to review our experience of OLT for HCC. Medical records of patients (< 18 yr) who underwent OLT for HCC were reviewed and compared to children who underwent OLT for HBL and for indications other than malignancy. There were 25 patients: HCC (10 cases) and HBL (15 cases). The actuarial patient survival for HCC at one and five yr was 100% and 83.3%, for the HBL group the survival was 86.7% at both one and five yr, and for indications (n = 377) other than malignancy the patient survival for pediatric OLT at our center was 87.7% and 84.7% at one and five yr, respectively. The actuarial recurrence free survival at five yr was 83.3% for HCC and 66.8% for HBL. In conclusion, OLT is a good therapeutic modality for children with HCC and HBL.